Slit1 Polyclonal Antibody, RBITC Conjugated

Secreted leucine-rich repeat-containing proteins 1-3 (Slit1-3) are secreted glycoproteins that influence axonal guidance and mediate normal neural development by acting as high-affinity signaling ligands for the repulsive guidance receptor, Roundabout (Robo) (1, 2) . Within the developing central nervous system (CNS) of different vertebrate systems, Slit proteins are expressed in equivalent regions, suggesting a conserved function among vertebrate homologs (3,4) . Slit is expressed in the midline of the central nervous system in both vertebrates and invertebrates, where it functions as a regulatory factor of mesodermal cell movement during gastrulation (5) . Slit2 is a short range inhibitory guidance cue for retinal ganglion cell (RGC) axons that may mediate spatial progression of RGCs (6,7) .

MEGF 4; MEGF4; Multiple EGF like domains protein 4; Multiple epidermal growth factor like domains 4; Multiple epidermal growth factor like domains protein 4; SLIL 1; SLIL1; Slit 1; SLIT 3; Slit homolog 1; Slit homolog 1 protein; Slit-1; Slit1; SLIT3; KIAA0813; SLIT1_HUMAN.