GNRHR2 Polyclonal Antibody, PE-Cy5.5 Conjugated
Product Specifications
Background
Gonadotropin-releasing hormone (GnRH) is released in a pulsatile manner that varies with the reproductive cycle. This hypothalamic hormone is transported to the pituitary, where it binds to specific receptors and regulates the synthesis and release of luteinizing hormone (LH) and follicle-stimulating hormone (FSH) . Localized to the cell membrane, GnRHR2 mediates its own receptor activity via association with G proteins, thereby activating a phosphatidylinositol-calcium second messenger system that regulates GnRHR2 function. GnRHR2 is thought to have potent antiproliferative effects on ovarian and endometrial cancer cells, suggesting a possible role in tumor suppression. Due to alternative splicing events, GnRHR2 is expressed as two isoforms.
Synonyms
GnRH IIR; Putative gonadotropin-releasing hormone II receptor; gonadotropin-releasing hormone type 2 receptor 2; GnRH-II-R; Type II GnRH receptor; GNRR2_HUMAN.
Cellular Locus
Cell membrane
Host
Rabbit
Immunogen
81-180/292
Target
GNRHR2
Clonality
Polyclonal
Isotype
IgG
Conjugation
PE-Cy5.5
Source
KLH conjugated synthetic peptide derived from human GNRHR2
Applications
WB
Purification
Purified by Protein A.
Excitation Emission
488nm/694nm
Concentration
1µg/µl
Dilution
WB (1:300-5000)
Buffer
Aqueous buffered solution containing 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
Modification
Unmodified
Storage Conditions
Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.
Predicted Cross Reactivity
Human, Pig
Frequently Asked Questions
More Discoveries
Explore Other Products
Browse additional items from our catalog
BNC682216-500 1x 500 µL
CD50 / ICAM3 (CG106), CF568 conjugate, 0.1mg/mL
Sign In for Pricing
View Details 
BNC680198-500 1x 500 µL
Cytokeratin 18 (DA7), CF568 conjugate, 0.1mg/mL
Sign In for Pricing
View Details 
BNC471171-100 1x 100 µL
CD34 (HPCA1/1171), CF647 conjugate, 0.1mg/mL
Sign In for Pricing
View Details