GNRHR2 Polyclonal Antibody, APC-Cy7 Conjugated
Product Specifications
Background
Gonadotropin-releasing hormone (GnRH) is released in a pulsatile manner that varies with the reproductive cycle. This hypothalamic hormone is transported to the pituitary, where it binds to specific receptors and regulates the synthesis and release of luteinizing hormone (LH) and follicle-stimulating hormone (FSH) . Localized to the cell membrane, GnRHR2 mediates its own receptor activity via association with G proteins, thereby activating a phosphatidylinositol-calcium second messenger system that regulates GnRHR2 function. GnRHR2 is thought to have potent antiproliferative effects on ovarian and endometrial cancer cells, suggesting a possible role in tumor suppression. Due to alternative splicing events, GnRHR2 is expressed as two isoforms.
Synonyms
GnRH IIR; Putative gonadotropin-releasing hormone II receptor; gonadotropin-releasing hormone type 2 receptor 2; GnRH-II-R; Type II GnRH receptor; GNRR2_HUMAN.
Cellular Locus
Cell membrane
Host
Rabbit
Immunogen
81-180/292
Target
GNRHR2
Clonality
Polyclonal
Isotype
IgG
Conjugation
APC-Cy7
Source
KLH conjugated synthetic peptide derived from human GNRHR2
Applications
WB, IF (IHC-P), IF (IHC-F), IF (ICC)
Purification
Purified by Protein A.
Excitation Emission
650nm/780nm
Concentration
1µg/µl
Dilution
WB (1:300-5000), IF (IHC-P) (1:50-200), IF (IHC-F) (1:50-200), IF (ICC) (1:50-200)
Buffer
Aqueous buffered solution containing 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
Modification
Unmodified
Storage Conditions
Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.
Predicted Cross Reactivity
Human, Pig
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