PCYT1A Polyclonal Antibody, PE-Cy5 Conjugated

Increase in fetal surfactant synthesis and lung maturity is caused by the glucocorticoidal induction of enzymes required for phosphatidylcholine synthesis towards the end of gestation (1) . The regulation of gestational age-dependent induction of phosphatidylcholine synthesis by glucocorticoids is still unclear (1) . The rate-controlling enzyme in the phosphatidylcholine biosynthetic pathway is CTP-phosphocholine cytidylyltransferase A (CCT A) (24) . In cultured eukaryotic cells, this enzyme is essential for survival (3) . The alpha isoform is located in the nucleus and is regulated by reversible phosphorylation and membrane association (3) . There is significant identity between the alpha-helical membrane-binding domains of CCT A and soybean oleosin (2) . Expressed CCT A has lipid-dependent cytidylyltransferase activity (5) . The gene which encodes CCT A maps to human chromosome 3q (4) .

CCT A; CCT alpha; CCT-alpha; Choline phosphate cytidylyltransferase A; Choline-phosphate cytidylyltransferase A; CT A; CT antibody CTP:phosphocholine cytidylyltransferase A; CTPCT; PCY1A_HUMAN; PCYT1; Pcyt1a; Phosphate cytidylyltransferase 1 choline alpha; Phosphate cytidylyltransferase 1 choline alpha isoform; Phosphorylcholine transferase A.