PCYT1A Polyclonal Antibody, Cy5.5 Conjugated

Increase in fetal surfactant synthesis and lung maturity is caused by the glucocorticoidal induction of enzymes required for phosphatidylcholine synthesis towards the end of gestation (1) . The regulation of gestational age-dependent induction of phosphatidylcholine synthesis by glucocorticoids is still unclear (1) . The rate-controlling enzyme in the phosphatidylcholine biosynthetic pathway is CTP-phosphocholine cytidylyltransferase A (CCT A) (24) . In cultured eukaryotic cells, this enzyme is essential for survival (3) . The alpha isoform is located in the nucleus and is regulated by reversible phosphorylation and membrane association (3) . There is significant identity between the alpha-helical membrane-binding domains of CCT A and soybean oleosin (2) . Expressed CCT A has lipid-dependent cytidylyltransferase activity (5) . The gene which encodes CCT A maps to human chromosome 3q (4) .

CCT A; CCT alpha; CCT-alpha; Choline phosphate cytidylyltransferase A; Choline-phosphate cytidylyltransferase A; CT A; CT antibody CTP:phosphocholine cytidylyltransferase A; CTPCT; PCY1A_HUMAN; PCYT1; Pcyt1a; Phosphate cytidylyltransferase 1 choline alpha; Phosphate cytidylyltransferase 1 choline alpha isoform; Phosphorylcholine transferase A.