C/EBP β (Acetyl Lys265) rabbit pAb

Function: Important transcriptional activator in the regulation of genes involved in immune and inflammatory responses. Specifically binds to an IL-1 response element in the IL-6 gene. NF-IL6 also binds to regulatory regions of several acute-phase and cytokines genes. It probably plays a role in the regulation of acute-phase reaction, inflammation and hemopoiesis. The consensus recognition site is 5'-T[TG]NNGNAA[TG]-3'. PTM: Sumoylated by polymeric chains of SUMO2 or SUMO3. similarity: Belongs to the bZIP family. similarity: Belongs to the bZIP family. C/EBP subfamily. similarity: Contains 1 bZIP domain. subunit: Binds DNA as a dimer and can form stable heterodimers with C/EBP alpha, delta and gamma. Interacts with TRIM28 and PTGES2. tissue specificity: Expressed at low levels in the lung, kidney and spleen.

Product Specifications

Background

Function:Important transcriptional activator in the regulation of genes involved in immune and inflammatory responses. Specifically binds to an IL-1 response element in the IL-6 gene. NF-IL6 also binds to regulatory regions of several acute-phase and cytokines genes. It probably plays a role in the regulation of acute-phase reaction, inflammation and hemopoiesis. The consensus recognition site is 5'-T[TG]NNGNAA[TG]-3'., PTM:Sumoylated by polymeric chains of SUMO2 or SUMO3., similarity:Belongs to the bZIP family., similarity:Belongs to the bZIP family. C/EBP subfamily., similarity:Contains 1 bZIP domain., subunit:Binds DNA as a dimer and can form stable heterodimers with C/EBP alpha, delta and gamma. Interacts with TRIM28 and PTGES2., tissue specificity:Expressed at low levels in the lung, kidney and spleen.

UniProt

P17676

Swiss Prot

P17676

Reactivity

Human; Mouse; Rat

Immunogen

Synthesized peptide derived from human C/EBP β (Acetyl Lys265)

Clonality

Polyclonal

Source

Rabbit

Applications

WB; ELISA

Concentration

1 mg/ml

Dilution

WB 1:1000-2000 ELISA 1:5000-20000

Molecular Weight

40kD

Storage Conditions

-20°C/1 year

Observed Molecular Weight

40kD

Fragment

IgG

Subcellular Location

Nucleus . Cytoplasm . Translocates to the nucleus when phosphorylated at Ser-288. In T-cells when sumoylated drawn to pericentric heterochromatin thereby allowing proliferation (By similarity) . .