9-Amino-NeuAc

9-Amino-NeuAc is a substrate of synthase. 9-Amino-NeuAc can be converted to CMP9-amino-NeuAc, activated to the corresponding CMPglycoside and transferred to asialoglycoprotein. 9-Amino-NeuAc can be used to target liposome synthesis while modulating tumor surface immunogenicity[1][2].

Product Specifications

CAS Number

[153232-60-1]

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Liposome

Type

Reference compound

Related Pathways

Metabolic Enzyme/Protease

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/9-amino-neuac.html

Purity

98.92

Solubility

DMSO : 50 mg/mL (ultrasonic)

Smiles

O[C@@H]([C@@](O[C@]1(O)C(O)=O)([H])[C@@H]([C@H](C1)O)NC(C)=O)[C@H](O)CN

Molecular Formula

C11H20N2O8

Molecular Weight

308.29

Precautions

H302, H315, H319, H335

References & Citations

[1]Zheng N, et al. Liposome-aided metabolic engineering of tumor surface immunogenicity. Bioorg Med Chem Lett. 2018 Aug 1;28 (14) :2550-2554.|[2]Gross H J, et al. Asialo- 1-acid glycoprotein resialylated with 9-amino-5-N-acetyl-d-neuraminic acid is resistant towards bacterial, viral and mammalian sialidases[J]. Glycoconjugate Journal, 1988, 5: 411-417.