Netarsudil (dimesylate)
Product Specifications
Product Name Alternative
AR-13324 (dimesylate)
UNSPSC Description
Netarsudil mesylate (AR-13324 mesylate) is a small-molecule inhibitor of Rho kinase and a norepinephrine transporter; reduces intraocular pressure (IOP) in normotensive monkey eyes.
Target Antigen
ROCK
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage;Cytoskeleton;Stem Cell/Wnt;TGF-beta/Smad
Field of Research
Others
Assay Protocol
https://www.medchemexpress.com/Netarsudil_mesylate.html
Purity
99.56
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
CC1=CC(C)=C(C(OCC2=CC=C([C@@H](CN)C(NC3=CC(C=CN=C4)=C4C=C3)=O)C=C2)=O)C=C1.CS(=O)(O)=O.CS(=O)(O)=O
Molecular Weight
645.74
References & Citations
[1]Wang RF, et al. Effect of 0.04% AR-13324, a ROCK, and norepinephrine transporter inhibitor, on aqueous humor dynamics in normotensive monkey eyes. J Glaucoma. 2015 Jan;24(1):51-4.|[2]Levy B, et al. Ocular hypotensive safety and systemic absorption of AR-13324 ophthalmic solution in normal volunteers. Am J Ophthalmol. 2015 May;159(5):980-5.e1.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-12798A/Netarsudil-dimesylate-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-12798A/Netarsudil-dimesylate-SDS-MedChemExpress.pdf
Clinical Information
Launched
CAS Number
1422144-42-0
Available Sizes
Curated Selection
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