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Bestrophin 4 Polyclonal Antibody, RBITC Conjugated

Product Specifications

Background

Bestrophin-4 is a 473 amino acid member of the Bestrophin family of proteins. Members of the Bestrophin family are transmembrane proteins that contain a high percentage of aromatic residues, a conserved RFP (Arg-Phe-Pro) motif and they function as anion channels. Bestrophin-4 acts as a calcium-sensitive chloride channel located in the cell membrane. It is believed that Bestrophin-4 also acts as a channel for other physiologically significant anions, such as bicarbonate. Bestrophin-4 is predominantly expressed in the colon, but can be found at low levels in testis, placenta, trachea, spinal chord, lung and retina.

Synonyms

BEST 4; BEST4; BEST-4; Bestrophin 4; Bestrophin4; Bestrophin-4; Vitellorm macular dystrophy 2 like 2; Vitellorm macular dystrophy 2 like protein 2; VMD2L2; BEST4_HUMAN.

Cellular Locus

Cell membrane

Host

Rabbit

Cross Reactivity

Human

Immunogen

151-250/473

Target

Bestrophin 4

Clonality

Polyclonal

Isotype

IgG

Conjugation

RBITC

Source

KLH conjugated synthetic peptide derived from human Bestrophin 4

Applications

WB, IF (IHC-P), IF (IHC-F), IF (ICC)

Purification

Purified by Protein A.

Excitation Emission

570nm/595nm

Concentration

1µg/µl

Dilution

WB (1:300-5000), IF (IHC-P) (1:50-200), IF (IHC-F) (1:50-200), IF (ICC) (1:50-200)

Buffer

Aqueous buffered solution containing 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.

Modification

Unmodified

Storage Conditions

Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Predicted Cross Reactivity

Dog, Cow, Sheep, Pig, Horse, Rabbit

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