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Phospho-CDK7 (Thr170) Polyclonal Antibody, APC-Cy5.5 Conjugated

Product Specifications

Background

The protein encoded by this gene is a member of the cyclin-dependent protein kinase (CDK) family. CDK family members are highly similar to the gene products of Saccharomyces cerevisiae cdc28, and Schizosaccharomyces pombe cdc2, and are known to be important regulators of cell cycle progression. This protein forms a trimeric complex with cyclin H and MAT1, which functions as a Cdk-activating kinase (CAK) . It is an essential component of the transcription factor TFIIH, that is involved in transcription initiation and DNA repair. This protein is thought to serve as a direct link between the regulation of transcription and the cell cycle.

Synonyms

CDK7 (phospho Thr170) ; CDK7 (phospho T170) ; Cyclin H; MAT1; Cyclin Dependent Kinase 7; CAK1; MO15; CDKN7; serine/threonine kinase; STK1; serine/threonine protein kinase 1; MO15 homolog, Xenopus laevis, cdk-activating kinase; Cdk-activating kinase; serine/threonine protein kinase MO15; homolog of Xenopus MO15 Cdk-activating kinase; kinase subunit of CAK; 39 KDa protein kinase; CR4 protein kinase; CRK4; CDK7_HUMAN.

Gene ID

1022

Swiss Prot

P50613

Modification Site

Thr170

Cellular Locus

Cytoplasm, Nucleus

Host

Rabbit

Cross Reactivity

Human

Target

Phospho-CDK7 (Thr170)

Clonality

Polyclonal

Isotype

IgG

Conjugation

APC-Cy5.5

Source

KLH conjugated Synthesised phosphopeptide derived from human CDK7 around the phosphorylation site of Thr170

Applications

WB, IF (IHC-P), IF (IHC-F), IF (ICC)

Purification

Purified by Protein A.

Excitation Emission

650nm/694nm

Concentration

1µg/µl

Dilution

WB (1:300-5000), IF (IHC-P) (1:50-200), IF (IHC-F) (1:50-200), IF (ICC) (1:50-200)

Buffer

Aqueous buffered solution containing 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.

Modification

Phosphorylation

Storage Conditions

Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Gene ID URL

1022

Predicted Cross Reactivity

Mouse, Rat, Dog, Pig, Horse, Rabbit

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