CACNA1B (N type) Polyclonal Antibody, AbBy Fluor™ 488 Conjugated
Product Specifications
Background
Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. The isoform alpha-1B gives rise to N-type calcium currents. N-type calcium channels belong to the 'high-voltage activated' (HVA) group and are blocked by omega-conotoxin-GVIA (omega-CTx-GVIA) and by omega-agatoxin-IIIA (omega-Aga-IIIA) . They are however insensitive to dihydropyridines (DHP), and omega-agatoxin-IVA (omega-Aga-IVA) . Calcium channels containing alpha-1B subunit may play a role in directed migration of immature neurons.
Synonyms
BIII; CACNN; DYT23; Cav2.2; CACNL1A5; Voltage-dependent N-type calcium channel subunit alpha-1B; Brain calcium channel III; Calcium channel, L type, alpha-1 polypeptide isoform 5; Voltage-gated calcium channel subunit alpha Cav2.2; CACNA1B; CACH5
Gene ID
774
Swiss Prot
Q00975
Cellular Locus
Cell membrane
Host
Rabbit
Cross Reactivity
Human
Immunogen
101-200/2339
Target
CACNA1B (N type)
Clonality
Polyclonal
Isotype
IgG
Conjugation
AbBy Fluor™ 488
Source
KLH conjugated synthetic peptide derived from human CACNA1B (N type)
Applications
IF (IHC-P), IF (IHC-F), IF (ICC)
Purification
Purified by Protein A.
Excitation Emission
499nm/519nm
Concentration
1µg/µl
Dilution
IF (IHC-P) (1:50-200), IF (IHC-F) (1:50-200), IF (ICC) (1:50-200)
Buffer
Aqueous buffered solution containing 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
Modification
Unmodified
Storage Conditions
Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.
Gene ID URL
774
Predicted Cross Reactivity
Mouse, Rat
Curated Selection
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