HHV11 DNA polymerase catalytic subunit Polyclonal Antibody, APC Conjugated

Product Specifications

Background

Replicates viral genomic DNA. The replication complex is composed of six viral proteins: the DNA polymerase, processivity factor, primase, primase-associated factor, helicase, and ssDNA-binding protein. Additionally, the polymerase contains an intrinsic ribonuclease H (RNase H) activity that specifically degrades RNA/DNA heteroduplexes or duplex DNA substrates in the 5' to 3' direction. Therefore, it can catalyze the excision of the RNA primers that initiate the synthesis of Okazaki fragments at a replication fork during viral DNA replication.

Synonyms

DPOL_HHV11; DNA polymerase catalytic subunit; UL30; HHV1gp046.

Cellular Locus

Nucleus

Host

Rabbit

Cross Reactivity

Virus

Immunogen

1131-1235/1235

Target

HHV11 DNA polymerase catalytic subunit

Clonality

Polyclonal

Isotype

IgG

Conjugation

APC

Source

KLH conjugated synthetic peptide derived from human Human herpesvirus 1 DNA polymerase catalytic subunit

Applications

WB, IF (IHC-P), IF (IHC-F), IF (ICC)

Purification

Purified by Protein A.

Excitation Emission

650nm/660nm

Concentration

1µg/µl

Dilution

WB (1:300-5000), IF (IHC-P) (1:50-200), IF (IHC-F) (1:50-200), IF (ICC) (1:50-200)

Buffer

Aqueous buffered solution containing 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.

Modification

Unmodified

Storage Conditions

Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Specificity

This antibody will detect both HHV1 and HHV2 DNA polymerase catalytic subunit

Cross Reactivity Details

HHV1

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