Phospho-c-ABL (Thr413) Polyclonal Antibody, APC Conjugated
Product Specifications
Background
The c Abl proto oncogene encodes a protein tyrosine kinase that is located in the cytoplasm and nucleus. In chronic myelogenous leukemia and in a subset of acute lymphoblastic leukemias, the c Abl proto oncogene undergoes a (9;22) chromosomal translocation producing a novel rearranged chromosome (the Philadelphia chromosome) As the result of the fusion of c Abl sequences from chromosome 9 to the Bcr gene on chromosome 22. The molecular consequence of this translocation is the generation of a chimeric Bcr/Abl mRNA encoding activated Abl protein tyrosine kinase.
Synonyms
C-Ablphospho Thr394; c-Ablphospho Thr394; p-c-AblThr394; Abelson Murine Leukemia Viral Oncogene Homolog 1; Abelson murine leukemia viral v abl oncogene homolog 1; Abl 1; ABL; Abl protein; Abl1; Bcr/c abl oncogene protein; JTK 7; JTK7; p150; Proto oncogene tyrosine protein kinase ABL1; Transformation gene oncogene ABL; v abl Abelson murine leukemia viral oncogene homolog 1; v abl; ABL1_HUMAN.
Gene ID
25
Modification Site
Thr394
Cellular Locus
Cytoplasm, Nucleus
Host
Rabbit
Cross Reactivity
Human, Rat
Target
Phospho-c-ABL (Thr413)
Clonality
Polyclonal
Isotype
IgG
Conjugation
APC
Source
KLH conjugated synthetic phosphopeptide derived from human c-Abl isoform b around the phosphorylation site of Thr394
Applications
IF (IHC-P), IF (IHC-F), IF (ICC)
Purification
Purified by Protein A.
Excitation Emission
650nm/660nm
Concentration
1µg/µl
Dilution
IF (IHC-P) (1:50-200), IF (IHC-F) (1:50-200), IF (ICC) (1:50-200)
Buffer
Aqueous buffered solution containing 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
Modification
Phosphorylation
Storage Conditions
Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.
Gene ID URL
25
Predicted Cross Reactivity
Mouse, Cow, Pig, Chicken, Rabbit, GuineaPig
Frequently Asked Questions
More Discoveries
Explore Other Products
Browse additional items from our catalog
GTR10477102 96 Well
Bovine Anti Activin A receptor antibody ELISA kit
Sign In for Pricing
View Details MBS6229533-01 0.1 mL
QDPR (Quinoid Dihydropteridine Reductase, DHPR, FLJ42391, PKU2, SDR33C1) (MaxLight 650)
Sign In for Pricing
View Details MBS6229533-02 5x 0.1 mL
QDPR (Quinoid Dihydropteridine Reductase, DHPR, FLJ42391, PKU2, SDR33C1) (MaxLight 650)
Sign In for Pricing
View Details