COMP Polyclonal Antibody, AbBy Fluor™ 750 Conjugated
Product Specifications
Background
May play a role in the structural integrity of cartilage via its interaction with other extracellular matrix proteins such as the collagens and fibronectin. Can mediate the interaction of chondrocytes with the cartilage extracellular matrix through interaction with cell surface integrin receptors. Could play a role in the pathogenesis of osteoarthritis. Potent suppressor of apoptosis in both primary chondrocytes and transformed cells. Suppresses apoptosis by blocking the activation of caspase-3 and by inducing the IAP family of survival proteins (BIRC3, BIRC2, BIRC5 and XIAP) . Essential for maintaining a vascular smooth muscle cells (VSMCs) contractile/differentiated phenotype under physiological and pathological stimuli. Maintains this phenotype of VSMCs by interacting with ITGA7 (By similarity) .
Synonyms
MED; EDM1; EPD1; PSACH; THBS5; Cartilage oligomeric matrix protein; COMP; Thrombospondin-5; TSP5
Gene ID
1311
Swiss Prot
P49747
Cellular Locus
Secreted, Extracellular matrix
Host
Rabbit
Cross Reactivity
Human
Immunogen
221-320/757
Target
COMP
Clonality
Polyclonal
Isotype
IgG
Conjugation
AbBy Fluor™ 750
Source
KLH conjugated synthetic peptide derived from human COMP
Applications
WB, IF (IHC-P), IF (IHC-F), IF (ICC)
Purification
Purified by Protein A.
Excitation Emission
749nm/775nm
Concentration
1µg/µl
Dilution
WB (1:300-5000), IF (IHC-P) (1:50-200), IF (IHC-F) (1:50-200), IF (ICC) (1:50-200)
Buffer
Aqueous buffered solution containing 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
Modification
Unmodified
Storage Conditions
Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.
Gene ID URL
1311
Predicted Cross Reactivity
Mouse, Rat, Dog, Cow, Sheep, Pig, Horse
Curated Selection
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