Larotinib
Product Specifications
UNSPSC Description
Larotinib is a potent broad-spectrum and orally active tyrosine kinase inhibitor (TKI) with EGFR as the main target with an IC50 of 0.6 nM[1].
Target Antigen
Btk; EGFR; IRAK
Type
Reference compound
Related Pathways
Immunology/Inflammation;JAK/STAT Signaling;Protein Tyrosine Kinase/RTK
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/larotinib.html
Solubility
DMSO : 125 mg/mL (ultrasonic)
Smiles
COC(C(OCCCN1C[C@]2([H])[C@](OCCO2)([H])C1)=C3)=CC4=C3C(NC5=CC(Cl)=C(C=C5)F)=NC=N4
Molecular Weight
488.94
References & Citations
[1]Liu J, et al. Phase I Trial to Evaluate the Tolerance, Pharmacokinetics and Efficacy of the Broad-Spectrum ErbB Family Inhibitor Larotinib Mesylate in Patients With Advanced Solid Tumors. Front Pharmacol. 2021 Feb 18;12:636324.
Shipping Conditions
Room Temperature
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-153110/Larotinib-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-153110/Larotinib-SDS-MedChemExpress.pdf
Clinical Information
Phase 2
CAS Number
1438072-11-7
Available Sizes
Curated Selection
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