Bay 65-1942 (hydrochloride)

Bay 65-1942 hydrochloride is an ATP-competitive and selective IKKβ inhibitor.

Product Specifications

CAS Number

[600734-06-3]

UNSPSC

12352005

Target

IKK

Type

Reference compound

Related Pathways

NF-κB

Applications

COVID-19-immunoregulation

Field of Research

Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/Bay-65-1942-hydrochloride.html

Concentration

10mM

Purity

99.12

Solubility

DMSO : 50 mg/mL (ultrasonic) |H2O : 2.17 mg/mL (ultrasonic)

Smiles

O=C1OCC2=C([C@H]3CNCCC3)C=C(C4=C(O)C=CC=C4OCC5CC5)N=C2N1.[H]Cl

Molecular Formula

C22H26ClN3O4

Molecular Weight

431.91

References & Citations

[1]Inhibition of IκB kinase-β protects dopamine neurons against lipopolysaccharide-induced neurotoxicity By Zhang, Feng; Qian, Li; Flood, Patrick M.; Shi, Jing-Shan; Hong, Jau-Shyong; Gao, Hui-Ming J Pharmacol Exp Ther. 2010 June; 333 (3) : 822-833.|[2]Cooper MJ, et al. Application of multiplexed kinase inhibitor beads to study kinome adaptations in drug-resistant leukemia. PLoS One. 2013 Jun 24;8 (6) :e66755.

Shipping Conditions

Room Temperature

Storage Conditions

4°C (Powder, sealed storage, away from moisture)

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Isoform

IKK-β

Citation 01

Cell Mol Immunol. 2023 Apr;20 (4) :351-364.|FASEB Bioadv. 2025 Oct 23;7 (10) :e70050.|Int Immunopharmacol. 2020 Nov;88:107020.|Oncogene. 2016 Aug 4;35 (31) :4036-47.