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Phospho-HP1 alpha (Tyr37) Polyclonal Antibody, Biotin Conjugated

Product Specifications

Background

This gene encodes a highly conserved nonhistone protein, which is a member of the heterochromatin protein family. The protein is enriched in the heterochromatin and associated with centromeres. The protein has a single N-terminal chromodomain which can bind to histone proteins via methylated lysine residues, and a C-terminal chromo shadow-domain (CSD) which is responsible for the homodimerization and interaction with a number of chromatin-associated nonhistone proteins. The encoded product is involved in the formation of functional kinetochore through interaction with essential kinetochore proteins. The gene has a pseudogene located on chromosome 3. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq].

Synonyms

Antigen p25; Cbx 5; Cbx5; CBX5_HUMAN; CG8409; Chromobox homolog 5 Drosophila HP1 alpha; Chromobox homolog 5 HP1 alpha homolog Drosophila; Chromobox homolog 5 HP1 alpha homolog, Drosophila; chromobox homolog 5; HP1 alpha homolog; Chromobox protein homolog 5; Chromobox protein homologue 5; Heterochromatin protein 1 alpha; Heterochromatin protein 1; Heterochromatin protein 1; HP 1; HP 1A; HP1 alpha homolog; HP1; HP1A; HP1Hs alpha; Suvar205; HP1a; HP1Hs-alpha; HP1 alpha; Antigen p25; Heterochromatin protein 1 homolog alpha.

Gene ID

23468

Modification Site

Tyr37

Cellular Locus

Nucleus

Host

Rabbit

Target

Phospho-HP1 alpha (Tyr37)

Clonality

Polyclonal

Isotype

IgG

Conjugation

Biotin

Source

KLH conjugated synthetic phosphopeptide derived from human CBX5 around the phosphorylation site of Tyr37

Applications

ELISA, IHC-P, IHC-F

Purification

Purified by Protein A.

Concentration

1µg/µl

Dilution

ELISA (1:500-1000), IHC-P (1:200-400), IHC-F (1:100-500)

Buffer

Aqueous buffered solution containing 0.01M TBS (pH 7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.

Modification

Phosphorylation

Storage Conditions

Store at -20°C for 12 months.

Gene ID URL

23468

Predicted Cross Reactivity

Human, Mouse, Rat, Dog, Cow

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