Collagen IV Polyclonal Antibody, PE Conjugated

Product Specifications

Background

Type IV collagen is the major structural component of glomerular basement membranes (GBM), forming a 'chicken-wire' meshwork together with laminins, proteoglycans and entactin/nidogen. Arresten, comprising the C-terminal NC1 domain, inhibits angiogenesis and tumor formation. The C-terminal half is found to possess the anti-angiogenic activity. Specifically inhibits endothelial cell proliferation, migration and tube formation. Inhibits expression of hypoxia-inducible factor 1alpha and ERK1/2 and p38 MAPK activation. Ligand for alpha1/beta1 integrin (By similarity) .

Synonyms

Bru; Raw; Svc; Col4a-1; Del (8) 44H; Collagen alpha-1 (IV) chain; Col4a1

Gene ID

12826

Swiss Prot

P02463

Cellular Locus

Secreted, Cell membrane, Extracellular matrix

Host

Rabbit

Cross Reactivity

Human

Immunogen

1401-1500/1669

Target

Collagen IV

Clonality

Polyclonal

Isotype

IgG

Conjugation

Source

KLH conjugated synthetic peptide derived from mouse Collagen alpha-1 (IV) chain

Applications

WB, FCM, IF (IHC-P), IF (IHC-F), IF (ICC)

Purification

Purified by Protein A.

Excitation Emission

496,564nm/578nm

Concentration

1µg/µl

Dilution

WB (1:300-5000), FCM (1:20-100), IF (IHC-P) (1:50-200), IF (IHC-F) (1:50-200), IF (ICC) (1:50-200)

Buffer

Aqueous buffered solution containing 0.01M TBS (pH 7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.

Modification

Unmodified

Storage Conditions

Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Specificity

This antibody has 79% cross reactivity with Collagen alpha-5 (IV) chain.

Gene ID URL

12826

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