Cyclin D3 Polyclonal Antibody, APC Conjugated
Product Specifications
Background
Regulatory component of the cyclin D3-CDK4 (DC) complex that phosphorylates and inhibits members of the retinoblastoma (RB) protein family including RB1 and regulates the cell-cycle during G (1) /S transition. Phosphorylation of RB1 allows dissociation of the transcription factor E2F from the RB/E2F complex and the subsequent transcription of E2F target genes which are responsible for the progression through the G (1) phase. Hypophosphorylates RB1 in early G (1) phase. Cyclin D-CDK4 complexes are major integrators of various mitogenenic and antimitogenic signals. Also substrate for SMAD3, phosphorylating SMAD3 in a cell-cycle-dependent manner and repressing its transcriptional activity. Component of the ternary complex, cyclin D3/CDK4/CDKN1B, required for nuclear translocation and activity of the cyclin D-CDK4 complex.
Synonyms
G1/S-specific cyclin-D3; CCND3
Gene ID
896
Swiss Prot
P30281
Cellular Locus
Cytoplasm, Nucleus, Cell membrane
Host
Rabbit
Cross Reactivity
Human, Mouse, Rat
Immunogen
121-220/292
Target
Cyclin D3
Clonality
Polyclonal
Isotype
IgG
Conjugation
APC
Source
KLH conjugated synthetic peptide derived from human Cyclin D3
Applications
WB, FCM, IF (IHC-P), IF (IHC-F), IF (ICC)
Purification
Purified by Protein A.
Excitation Emission
650nm/660nm
Concentration
1µg/µl
Dilution
WB (1:300-5000), FCM (1:20-100), IF (IHC-P) (1:50-200), IF (IHC-F) (1:50-200), IF (ICC) (1:50-200)
Buffer
Aqueous buffered solution containing 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
Modification
Unmodified
Storage Conditions
Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.
Product Datasheet
https://www.biossantibodies.com/datasheets/bs-0660R-APC
Gene ID URL
896
Predicted Cross Reactivity
Dog, Cow, Pig, Rabbit
Curated Selection
Explore Other Products
Discover premium biology products from our extensive collection of 20M+ items
MBS7215450-01 48 Well
Guinea pig Solute carrier family 41 member 2 (SLC41A2) ELISA Kit
Ask
View Details 
MBS7215450-02 96 Well
Guinea pig Solute carrier family 41 member 2 (SLC41A2) ELISA Kit
Ask
View Details 
MBS7215450-03 5x 96 Well
Guinea pig Solute carrier family 41 member 2 (SLC41A2) ELISA Kit
Ask
View Details 
MBS7215450-04 10x 96 Well
Guinea pig Solute carrier family 41 member 2 (SLC41A2) ELISA Kit
Ask
View Details MBS1122438-01 0.02 mg (E-Coli)
Recombinant Mycobacterium leprae Translation initiation factor IF-1 (infA)
Ask
View Details MBS1122438-02 0.1 mg (E-Coli)
Recombinant Mycobacterium leprae Translation initiation factor IF-1 (infA)
Ask
View Details