Angiotensin II Polyclonal Antibody
Product Specifications
Background
Essential component of the renin-angiotensin system (RAS), a potent regulator of blood pressure, body fluid and electrolyte homeostasis. Angiotensin-2: acts directly on vascular smooth muscle as a potent vasoconstrictor, affects cardiac contractility and heart rate through its action on the sympathetic nervous system, and alters renal sodium and water absorption through its ability to stimulate the zona glomerulosa cells of the adrenal cortex to synthesize and secrete aldosterone. Angiotensin-3: stimulates aldosterone release. Angiotensin 1-7: is a ligand for the G-protein coupled receptor MAS1. Has vasodilator and antidiuretic effects. Has an antithrombotic effect that involves MAS1-mediated release of nitric oxide from platelets.
Synonyms
Alpha 1 antiproteinase, antitrypsin; Ang II; ANG III; Angiotensin I; Angiotensin II; Angiotensin III; Angiotensinogen; Angiotensinogen serpin peptidase inhibitor, clade A member 8; ANHU; Pre angiotensinogen; Serine or cysteine proteinase inhibitor; Serpin A8; SERPINA8; AT-2; AT-II; ANGT_HUMAN.
Gene ID
183
Cellular Locus
Secreted
Host
Rabbit
Cross Reactivity
Human
Immunogen
34-41/485
Target
Angiotensin II
Clonality
Polyclonal
Isotype
IgG
Conjugation
Unconjugated
Source
MAP conjugated synthetic peptide derived from human Angiotensin II
Applications
WB, IHC-P, IHC-F, IF, Flow-Cyt
Purification
Purified by Protein A.
Concentration
1µg/µl
Dilution
WB (1:300-5000), IHC-P (1:200-400), IHC-F (1:100-500), IF (), Flow-Cyt (1ug/Test)
Buffer
0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
Modification
Unmodified
Storage Conditions
Store at -20°C for 12 months.
Specificity
The immunogen used generate this antibody is DRVYIHPF, corresponding to amino acids 34-41 of human Angiotensinogen.
Gene ID URL
183
Curated Selection
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