FADD Polyclonal Antibody, PE-Cy5.5 Conjugated

Apoptotic adaptor molecule that recruits caspase-8 or caspase-10 to the activated Fas (CD95) or TNFR-1 receptors. The resulting aggregate called the death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation. Active caspase-8 initiates the subsequent cascade of caspases mediating apoptosis (By similarity) . Involved in interferon-mediated antiviral immune response, playing a role in the positive regulation of interferon signaling (By similarity) .

Mort1/FADD; FAS-associated death domain protein; FAS-associating death domain-containing protein; Mediator of receptor induced toxicity; Protein FADD; Fadd; Mort1