Dnmt3a Polyclonal Antibody, Biotin Conjugated
Product Specifications
Background
Required for genome-wide de novo methylation and is essential for the establishment of DNA methylation patterns during development. DNA methylation is coordinated with methylation of histones. It modifies DNA in a non-processive manner and also methylates non-CpG sites. May preferentially methylate DNA linker between 2 nucleosomal cores and is inhibited by histone H1. Plays a role in paternal and maternal imprinting. Required for methylation of most imprinted loci in germ cells. Acts as a transcriptional corepressor for ZBTB18. Recruited to trimethylated 'Lys-36' of histone H3 (H3K36me3) sites. Can actively repress transcription through the recruitment of HDAC activity.
Synonyms
TBRS; DNMT3A2; M.HsaIIIA; DNA (cytosine-5) -methyltransferase 3A; Dnmt3a; DNA methyltransferase HsaIIIA; DNA MTase HsaIIIA
Gene ID
1788
Swiss Prot
Q9Y6K1
Cellular Locus
Cytoplasm, Nucleus
Host
Rabbit
Cross Reactivity
Human, Mouse, Rat
Immunogen
26-100/912
Target
Dnmt3a
Clonality
Polyclonal
Isotype
IgG
Conjugation
Biotin
Source
KLH conjugated synthetic peptide derived from human Dnmt3a
Applications
IHC-P, IHC-F
Purification
Purified by Protein A.
Concentration
1µg/µl
Dilution
IHC-P (1:200-400), IHC-F (1:100-500)
Buffer
Aqueous buffered solution containing 0.01M TBS (pH 7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
Modification
Unmodified
Storage Conditions
Store at -20°C for 12 months.
Gene ID URL
1788
Predicted Cross Reactivity
Cow
Frequently Asked Questions
More Discoveries
Explore Other Products
Browse additional items from our catalog
![Mouse Monoclonal CD23/Fc epsilon RII Antibody (MM0164-2C23) [PE/Cy7]](https://cdn.genprice.uk/genprice/uk/genprice5.webp)
NBP2-12152PECY7 0.1 mL
Mouse Monoclonal CD23/Fc epsilon RII Antibody (MM0164-2C23) [PE/Cy7]
Sign In for Pricing
View Details 
MBS6287128-01 0.1 mL
CNDP2, CT (CNDP2, CN2, CPGL, PEPA, Cytosolic non-specific dipeptidase, CNDP dipeptidase 2, Glutamate carboxypeptidase-like protein 1, Peptidase A) (MaxLight 750)
Sign In for Pricing
View Details MBS6287128-02 5x 0.1 mL
CNDP2, CT (CNDP2, CN2, CPGL, PEPA, Cytosolic non-specific dipeptidase, CNDP dipeptidase 2, Glutamate carboxypeptidase-like protein 1, Peptidase A) (MaxLight 750)
Sign In for Pricing
View Details K3317304 1.0 µg DNA
Nthl1 sgRNA CRISPR Lentivector (Mouse) (Target 3)
Sign In for Pricing
View Details