WNK4 Polyclonal Antibody, PE-Cy5 Conjugated
Product Specifications
Background
Regulates the activity of the thiazide-sensitive Na-Cl cotransporter, SLC12A3, by phosphorylation which appears to prevent membrane trafficking of SLC12A3. Also inhibits the renal K (+) channel, KCNJ1, via a kinase-independent mechanism by which it induces clearance of the protein from the cell surface by clathrin-dependent endocytosis. WNK4 appears to act as a molecular switch that can vary the balance between NaCl reabsorption and K (+) secretion to maintain integrated homeostasis.
Synonyms
PHA 2B; PHA2B; PRKWNK 4; PRKWNK4; Protein kinase lysine deficient 4; Protein kinase with no lysine 4; Serine/threonine protein kinase WNK4; WNK lysine deficient protein kinase 4; WNK4_HUMAN.
Gene ID
65266
Cellular Locus
Cytoplasm
Host
Rabbit
Cross Reactivity
Mouse
Immunogen
351-450/1243
Target
WNK4
Clonality
Polyclonal
Isotype
IgG
Conjugation
PE-Cy5
Source
KLH conjugated synthetic peptide derived from human WNK4
Applications
WB
Purification
Purified by Protein A.
Excitation Emission
488nm/670nm
Concentration
1µg/µl
Dilution
WB (1:300-5000)
Buffer
Aqueous buffered solution containing 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
Modification
Unmodified
Storage Conditions
Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.
Gene ID URL
65266
Predicted Cross Reactivity
Human, Rat
Curated Selection
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