WNK4 Polyclonal Antibody, HRP Conjugated
Product Specifications
Background
Regulates the activity of the thiazide-sensitive Na-Cl cotransporter, SLC12A3, by phosphorylation which appears to prevent membrane trafficking of SLC12A3. Also inhibits the renal K (+) channel, KCNJ1, via a kinase-independent mechanism by which it induces clearance of the protein from the cell surface by clathrin-dependent endocytosis. WNK4 appears to act as a molecular switch that can vary the balance between NaCl reabsorption and K (+) secretion to maintain integrated homeostasis.
Synonyms
PHA 2B; PHA2B; PRKWNK 4; PRKWNK4; Protein kinase lysine deficient 4; Protein kinase with no lysine 4; Serine/threonine protein kinase WNK4; WNK lysine deficient protein kinase 4; WNK4_HUMAN.
Gene ID
65266
Cellular Locus
Cytoplasm
Host
Rabbit
Cross Reactivity
Mouse
Immunogen
351-450/1243
Target
WNK4
Clonality
Polyclonal
Isotype
IgG
Conjugation
HRP
Source
KLH conjugated synthetic peptide derived from human WNK4
Applications
WB, ELISA
Purification
Purified by Protein A.
Concentration
1µg/µl
Dilution
WB (1:300-5000), ELISA (1:500-1000)
Buffer
Aqueous buffered solution containing 0.01M TBS (pH 7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
Modification
Unmodified
Storage Conditions
Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.
Gene ID URL
65266
Predicted Cross Reactivity
Human, Rat
Curated Selection
Explore Other Products
Discover premium biology products from our extensive collection of 20M+ items
034898-ML650 100 µL
EBP, CT (EBP, 3-beta-hydroxysteroid-Delta (8), Delta (7) -isomerase, Cholestenol Delta-isomerase, Delta (8) -Delta (7) sterol isomerase, Emopamil-binding protein) (MaxLight 650) discontinued
Ask
View Details 
MBS7187032 Inquire
Rabbit anti-Oryza sativa subsp. japonica (Rice) LOC_Os04g04640 Polyclonal Antibody
Ask
View Details