H5N1 Matrix Protein 2 Polyclonal Antibody, Biotin Conjugated
Product Specifications
Background
Forms a proton-selective ion channel that is necessary for the efficient release of the viral genome during virus entry. After attaching to the cell surface, the virion enters the cell by endocytosis. Acidification of the endosome triggers M2 ion channel activity. The influx of protons into virion interior is believed to disrupt interactions between the viral ribonucleoprotein (RNP), matrix protein 1 (M1), and lipid bilayers, thereby freeing the viral genome from interaction with viral proteins and enabling RNA segments to migrate to the host cell nucleus, where influenza virus RNA transcription and replication occur. Also plays a role in viral proteins secretory pathway. Elevates the intravesicular pH of normally acidic compartments, such as trans-Golgi network, preventing newly formed hemagglutinin from premature switching to the fusion-active conformation
Synonyms
Avian influenza Matrix Protein-2; Influenza A virus H7N7 H9N2 H13N6 H16N3 H1N1 N2N1 H3N2 H2N2
Host
Rabbit
Cross Reactivity
Virus
Immunogen
2-60/97
Target
H5N1 Matrix Protein 2
Clonality
Polyclonal
Isotype
IgG
Conjugation
Biotin
Source
KLH conjugated synthetic peptide derived from Influenza A virus H5N1 Matrix Protein-2
Applications
ELISA, IHC-P, IHC-F
Purification
Purified by Protein A.
Concentration
1µg/µl
Dilution
ELISA (1:500-1000), IHC-P (1:200-400), IHC-F (1:100-500)
Buffer
Aqueous buffered solution containing 0.01M TBS (pH 7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
Modification
Unmodified
Storage Conditions
Store at -20°C for 12 months.
Specificity
This antibody will recognize many Influenza A virus strains
Cross Reactivity Details
Influenza A virus
Curated Selection
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