GTP cyclohydrolase 1 Polyclonal Antibody, Cy3 Conjugated

Product Specifications

Background

GTP cyclohydrolase I (also designated dopa-responsive dystonia) catalyzes the conversion of GTP to D-erythro-7,8-dihydroneopterin triphosphate, the first and rate-limiting step in tetrahydrobiopterin (BH4) biosynthesis. Tetrahydrobiopterin is an essential cofactor for 3 aromatic amino acid monooxygenases: phenylalanine, tyrosine, and tryptophan hydroxylases. Animals can synthesize tetrahydrobiopterin in vivo from GTP through several enzymatic reactions.

Synonyms

GTP-CH-1; DYT 5; DYT5; GCH 1; GCH; GCH1; GTP CH 1; GTP CH I; GTP cyclohydrolase 1 dopa responsive dystonia; GTP cyclohydrolase 1; GTP cyclohydrolase I; GTPCH 1; GTPCH1; Guanosine 5' triphosphate cyclohydrolase I.

Gene ID

2643

Cellular Locus

Cytoplasm, Nucleus

Host

Rabbit

Cross Reactivity

Mouse

Immunogen

34-110/250

Target

GTP cyclohydrolase 1

Clonality

Polyclonal

Isotype

IgG

Conjugation

Cy3

Source

KLH conjugated synthetic peptide derived from human GTP-CH-1

Applications

WB, IF (IHC-P), IF (IHC-F), IF (ICC)

Purification

Purified by Protein A.

Excitation Emission

512,550nm/570,615nm

Concentration

1µg/µl

Dilution

WB (1:300-5000), IF (IHC-P) (1:50-200), IF (IHC-F) (1:50-200), IF (ICC) (1:50-200)

Buffer

Aqueous buffered solution containing 0.01M TBS (pH 7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.

Modification

Unmodified

Storage Conditions

Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Gene ID URL

2643

Predicted Cross Reactivity

Human, Rat

Curated Selection

Explore Other Products

Discover premium biology products from our extensive collection of 20M+ items

MBS6498939-01 0.1 mL

Separin, Phosphorylated (Ser801) (ESPL1, Separase, Caspase-like Protein ESPL1, Extra Spindle Poles-like 1 Protein, ESP1, KIAA0165) (MaxLight 405)

Ask

View Details

MBS6498939-02 5x 0.1 mL

Separin, Phosphorylated (Ser801) (ESPL1, Separase, Caspase-like Protein ESPL1, Extra Spindle Poles-like 1 Protein, ESP1, KIAA0165) (MaxLight 405)

Ask

View Details

ABC-KH10953 1 Vial

Human OSBPL7 knockout cell line

Ask

View Details

PVT36812 2 µg

pCMV-SPORT6-ANAPC10 Plasmid

Ask

View Details

NBP2-97431CL1 0.1 mL

Rabbit Polyclonal ARHGEF39 Antibody [CoraFluor 1]

Ask

View Details

A17422-50UG 50 µg

CLASP2 Antibody

Ask

View Details