MEK5 Recombinant Antibody, APC Conjugated
Product Specifications
Background
Acts as a scaffold for the formation of a ternary MAP3K2/MAP3K3-MAP3K5-MAPK7 signaling complex. Activation of this pathway appears to play a critical role in protecting cells from stress-induced apoptosis, neuronal survival and cardiac development and angiogenesis. As part of the MAPK/ERK signaling pathway, acts as a negative regulator of apoptosis in cardiomyocytes via promotion of STUB1/CHIP-mediated ubiquitination and degradation of ICER-type isoforms of CREM.
Synonyms
MAP2K5; HsT17454; MAPKK 5; MEK 5; MAPKK5; MEK5; MKK5; MAP kinase kinase 5; PRKMK5; MAP kinase kinase MEK5b; MAPK/ERK kinase 5.
Gene ID
5607
Swiss Prot
Q13163
Host
Rabbit
Cross Reactivity
Human
Target
MEK5
Clonality
Recombinant
Conjugation
APC
Source
KLH conjugated synthetic peptide derived from human MEK5
Applications
WB
Purification
Purified by Protein A.
Excitation Emission
650nm/660nm
Concentration
Lot dependent
Dilution
WB (1:300-5000)
Buffer
Aqueous buffered solution containing 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
Modification
Unmodified
Storage Conditions
Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.
Gene ID URL
5607
Isotype
IgG
Curated Selection
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