P45 NF-E2 Recombinant Antibody, Biotin Conjugated
Product Specifications
Background
Component of the NF-E2 complex essential for regulating erythroid and megakaryocytic maturation and differentiation. Binds to the hypersensitive site 2 (HS2) of the beta-globin control region (LCR) . This subunit (NFE2) recognizes the TCAT/C sequence of the AP-1-like core palindrome present in a number of erythroid and megakaryocytic gene promoters. Requires MAFK or other small MAF proteins for binding to the NF-E2 motif. May play a role in all aspects of hemoglobin production from globin and heme synthesis to procurement of iron.
Synonyms
Nfe2 ; Nuclear factor; p45 NFE2.
Gene ID
4778
Swiss Prot
Q16621
Cellular Locus
Nucleus
Host
Rabbit
Cross Reactivity
Human
Target
P45 NF-E2
Clonality
Recombinant
Conjugation
Biotin
Source
KLH conjugated synthetic peptide derived from human NFE2
Applications
WB, IHC-P, IHC-F, IP
Purification
Purified by Protein A.
Concentration
Lot dependent
Dilution
WB (1:300-5000), IHC-P (1:200-400), IHC-F (1:100-500), IP (1-2ug)
Buffer
Aqueous buffered solution containing 0.01M TBS (pH 7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
Modification
Unmodified
Storage Conditions
Store at -20°C for 12 months.
Gene ID URL
4778
Isotype
IgG
Curated Selection
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