BAY32-5915
BAY32-5915 is a potent IKKα inhibitor with an IC50 value of 60 nM. BAY32-5915 has not affect Doxorubicin (HY-15142A) -induced NF-κB activation[1].
Product Specifications
CAS Number
[1571-30-8]
UNSPSC
12352005
Hazard Statement
H315, H319, H335
Target
IKK
Type
Reference compound
Related Pathways
NF-κB
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/bay32-5915.html
Concentration
10mM
Purity
99.60
Solubility
DMSO : 125 mg/mL (ultrasonic)
Smiles
O=C(C1=NC2=C(O)C=CC=C2C=C1)O
Molecular Formula
C10H7NO3
Molecular Weight
189.17
Precautions
H315, H319, H335
References & Citations
[1]Pletz N, et, al. Doxorubicin-induced activation of NF-κB in melanoma cells is abrogated by inhibition of IKKβ, but not by a novel IKKα inhibitor. Exp Dermatol. 2012 Apr;21 (4) :301-4.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
IKK-α
Available Sizes
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