RGMA Recombinant Antibody, Biotin Conjugated
Product Specifications
Background
Member of the repulsive guidance molecule (RGM) family that performs several functions in the developing and adult nervous system. Regulates cephalic neural tube closure, inhibits neurite outgrowth and cortical neuron branching, and the formation of mature synapses. Binding to its receptor NEO1/neogenin induces activation of RHOA-ROCK1/Rho-kinase signaling pathway through UNC5B-ARHGEF12/LARG-PTK2/FAK1 cascade, leading to collapse of the neuronal growth cone and neurite outgrowth inhibition.
Synonyms
Repulsive guidance molecule A; RGM; RGM domain family member A; RGMA.
Gene ID
56963
Swiss Prot
Q96B86
Cellular Locus
Cell membrane
Host
Rabbit
Cross Reactivity
Human, Mouse, Rat
Target
RGMA
Clonality
Recombinant
Conjugation
Biotin
Source
KLH conjugated synthetic peptide derived from human Repulsive guidance molecule A
Applications
WB
Purification
Purified by Protein A.
Concentration
Lot dependent
Dilution
WB (1:300-5000)
Buffer
Aqueous buffered solution containing 0.01M TBS (pH 7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
Modification
Unmodified
Storage Conditions
Store at -20°C for 12 months.
Gene ID URL
56963
Isotype
IgG
Curated Selection
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