DMJ-I-228

DMJ-I-228 is a CD4-mimetic. DMJ-I-228 binds to HIV-1 gp120 within the conserved Phe 43 cavity near the CD4-binding site, thereby blocking CD4 binding and inhibiting HIV-1 infection[1].

Product Specifications

CAS Number

[1374035-59-2]

UNSPSC

12352005

Hazard Statement

H302-H372-H411

Target

HIV

Type

Reference compound

Related Pathways

Anti-infection

Applications

COVID-19-anti-virus

Field of Research

Infection

Assay Protocol

https://www.medchemexpress.com/dmj-i-228.html

Smiles

O=CO.O=C(N[C@@H]1[C@@H](NC(N)=N)CC2=C1C=CC=C2)C(NC3=CC=C(Cl)C(F)=C3)=O

Molecular Formula

C19H19ClFN5O4

Molecular Weight

435.84

Precautions

P260-P264-P273-P391-P501

References & Citations

[1]Madani N, et al. CD4-mimetic small molecules sensitize human immunodeficiency virus to vaccine-elicited antibodies. J Virol. 2014 Jun;88 (12) :6542-55.