P21 (Acetyl Lys154) rabbit pAb

Function: May be the important intermediate by which p53 mediates its role as an inhibitor of cellular proliferation in response to DNA damage. Binds to and inhibits cyclin-dependent kinase activity, preventing phosphorylation of critical cyclin-dependent kinase substrates and blocking cell cycle progression. induction: By p53, mezerein (antileukemic compound) and interferon beta. PTM: Phosphorylation of Thr-145 by Akt or of Ser-146 by PKC impairs binding to PCNA. similarity: Belongs to the CDI family. tissue specificity: Expressed in all adult human tissues, with 5-fold lower levels observed in the brain.