Dehydro-ZINC39395747
Product Specifications
UNSPSC Description
Dehydro-ZINC39395747 is a derivative of ZINC39395747. ZINC39395747 is a potent cytochrome b5 reductase 3 (CYB5R3) inhibitor with an IC50 of 9.14 μM and a Kd of 1.11 μM. ZINC39395747 can increase NO bioavailability in vascular cells[1].
Target Antigen
Cytochrome P450
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Applications
COVID-19-immunoregulation
Field of Research
Cardiovascular Disease
Assay Protocol
https://www.medchemexpress.com/dehydro-zinc39395747.html
Purity
99.20
Solubility
DMSO : 10 mg/mL (ultrasonic;adjust pH to 6 with HCl)
Smiles
O=C(C=C(CSC1=NC2=CC=CC=C2O1)N3)NC3=S
Molecular Weight
291.35
References & Citations
[1]Rahaman MM, et al. Structure Guided Chemical Modifications of Propylthiouracil Reveal Novel Small Molecule Inhibitors of Cytochrome b5 Reductase 3 That Increase Nitric Oxide Bioavailability. J Biol Chem. 2015 Jul 3;290(27):16861-72.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-103061/Dehydro-ZINC39395747-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-103061/Dehydro-ZINC39395747-SDS-MedChemExpress.pdf
Clinical Information
No Development Reported
CAS Number
433248-87-4
Available Sizes
Curated Selection
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