Dehydro-ZINC39395747

Dehydro-ZINC39395747 is a derivative of ZINC39395747. ZINC39395747 is a potent cytochrome b5 reductase 3 (CYB5R3) inhibitor with an IC50 of 9.14 μM and a Kd of 1.11 μM. ZINC39395747 can increase NO bioavailability in vascular cells[1].

Product Specifications

CAS Number

[433248-87-4]

UNSPSC

12352005

Target

Cytochrome P450

Type

Reference compound

Related Pathways

Metabolic Enzyme/Protease

Applications

COVID-19-immunoregulation

Field of Research

Cardiovascular Disease

Assay Protocol

https://www.medchemexpress.com/dehydro-zinc39395747.html

Purity

98.07

Solubility

DMSO : 10 mg/mL (ultrasonic; adjust pH to 6 with HCl)

Smiles

O=C(C=C(CSC1=NC2=CC=CC=C2O1)N3)NC3=S

Molecular Formula

C12H9N3O2S2

Molecular Weight

291.35

References & Citations

[1]Rahaman MM, et al. Structure Guided Chemical Modifications of Propylthiouracil Reveal Novel Small Molecule Inhibitors of Cytochrome b5 Reductase 3 That Increase Nitric Oxide Bioavailability. J Biol Chem. 2015 Jul 3;290 (27) :16861-72.