Afimetoran
Afimetoran (BMS-986256) is an orally active, selective, and highly bioavailable TLR7/8 antagonist. Afimetoran (BMS-986256) can inhibit TLR7/8 activation of the NF-κB pathway and reverse TLR7 mediated resistance to steroid induced apoptosis in plasma cell like dendritic cells (pDCs) . Afimetoran (BMS-986256) can be used for research on inflammation and autoimmune diseases (systemic lupus erythematosus) [1][2].
Product Specifications
CAS Number
2171019-55-7
Product Name Alternative
BMS-986256
UNSPSC
12352005
Hazard Statement
H315, H319
Target
Apoptosis; NF-κB; Toll-like Receptor (TLR)
Type
Reference compound
Related Pathways
Apoptosis; Immunology/Inflammation; NF-κB
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/afimetoran.html
Purity
99.37
Solubility
DMSO : 100 mg/mL (ultrasonic; adjust pH to 2 with HCl) |Ethanol : 2 mg/mL (ultrasonic; warming; heat to 60°C)
Smiles
O=C(CN1CCC(CC1)C2=CC=C3NC(C4=CN5N=CN=C5C(C)=C4C)=C(C(C)C)C3=C2)N
Molecular Formula
C26H32N6O
Molecular Weight
444.57
Precautions
H315, H319
References & Citations
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
Phase 2
Available Sizes
Frequently Asked Questions
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