PEN2 Recombinant Antibody, Biotin Conjugated
Product Specifications
Background
Essential subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors and APP.The gamma-secretase complex plays a role in Notch and Wnt signaling cascades and regulation of downstream processes via its role in processing key regulatory proteins, and by regulating cytosolic CTNNB1 levels (Probable) . PSENEN modulates both endoproteolysis of presenilin and gamma-secretase activity.
Synonyms
PEN 2; PSEN2; psenen.
Gene ID
55851
Swiss Prot
Q9NZ42
Cellular Locus
Cytoplasm, Cell membrane
Host
Rabbit
Cross Reactivity
Human, Mouse, Rat
Target
PEN2
Clonality
Recombinant
Conjugation
Biotin
Source
KLH conjugated synthetic peptide derived from human PEN 2
Applications
WB, IHC-P, IHC-F
Purification
Purified by Protein A.
Concentration
Lot dependent
Dilution
WB (1:300-5000), IHC-P (1:200-400), IHC-F (1:100-500)
Buffer
Aqueous buffered solution containing 0.01M TBS (pH 7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
Modification
Unmodified
Storage Conditions
Store at -20°C for 12 months.
Gene ID URL
55851
Isotype
IgG
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