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DARC Recombinant Antibody, HRP Conjugated

Product Specifications

Background

Atypical chemokine receptor that controls chemokine levels and localization via high-affinity chemokine binding that is uncoupled from classic ligand-driven signal transduction cascades, resulting instead in chemokine sequestration, degradation, or transcytosis. Also known as interceptor (internalizing receptor) or chemokine-scavenging receptor or chemokine decoy receptor. Has a promiscuous chemokine-binding profile, interacting with inflammatory chemokines of both the CXC and the CC subfamilies but not with homeostatic chemokines.

Synonyms

CCBP1; CD234; DARC; Dfy; FY; GPD; GpFy; WBCQ1.

Gene ID

2532

Swiss Prot

Q16570

Cellular Locus

Cell membrane

Host

Rabbit

Cross Reactivity

Human, Mouse

Target

DARC

Clonality

Recombinant

Conjugation

HRP

Source

KLH conjugated synthetic peptide derived from human Atypical chemokine receptor 1

Applications

IHC-P, IHC-F

Purification

Purified by Protein A.

Concentration

Lot dependent

Dilution

IHC-P (1:200-400), IHC-F (1:100-500)

Buffer

Aqueous buffered solution containing 0.01M TBS (pH 7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.

Modification

Unmodified

Storage Conditions

Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Gene ID URL

2532

Isotype

IgG

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