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COREST Recombinant Antibody, PE-Cy7 Conjugated

Product Specifications

Background

Essential component of the BHC complex, a corepressor complex that represses transcription of neuron-specific genes in non-neuronal cells. The BHC complex is recruited at RE1/NRSE sites by REST and acts by deacetylating and demethylating specific sites on histones, thereby acting as a chromatin modifier. In the BHC complex, it serves as a molecular beacon for the recruitment of molecular machinery, including MeCP2 and SUV39H1, that imposes silencing across a chromosomal interval.

Synonyms

COREST; Nr2b2; RCOR; Rcor1; Rxrb.

Gene ID

23186

Swiss Prot

Q9UKL0

Cellular Locus

Nucleus

Host

Rabbit

Cross Reactivity

Human, Mouse, Rat

Target

COREST

Clonality

Recombinant

Conjugation

PE-Cy7

Source

KLH conjugated synthetic peptide derived from human REST corepressor 1

Applications

WB

Purification

Purified by Protein A.

Excitation Emission

488nm/780nm

Concentration

Lot dependent

Dilution

WB (1:300-5000)

Buffer

Aqueous buffered solution containing 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.

Modification

Unmodified

Storage Conditions

Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Gene ID URL

23186

Isotype

IgG

Curated Selection

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