MELK Recombinant Antibody, HRP Conjugated
Product Specifications
Background
Serine/threonine-protein kinase involved in various processes such as cell cycle regulation, self-renewal of stem cells, apoptosis and splicing regulation. Has a broad substrate specificity; phosphorylates BCL2L14, CDC25B, MAP3K5/ASK1 and ZNF622. Acts as an activator of apoptosis by phosphorylating and activating MAP3K5/ASK1. Acts as a regulator of cell cycle, notably by mediating phosphorylation of CDC25B, promoting localization of CDC25B to the centrosome and the spindle poles during mitosis.
Synonyms
HMELK; hPK38; MELK; mKIAA0175; MPK38.
Gene ID
9833
Swiss Prot
Q14680
Cellular Locus
Cytoplasm
Host
Rabbit
Cross Reactivity
Human
Target
MELK
Clonality
Recombinant
Conjugation
HRP
Source
KLH conjugated synthetic peptide derived from human MELK
Applications
WB
Purification
Purified by Protein A.
Concentration
Lot dependent
Dilution
WB (1:300-5000)
Buffer
Aqueous buffered solution containing 0.01M TBS (pH 7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
Modification
Unmodified
Storage Conditions
Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.
Gene ID URL
9833
Isotype
IgG
Curated Selection
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