Izeltabart
Izeltabart (MGA021) is a humanized IgG1 monoclonal antibody targeting ADAM9, which can be used as an ADC Antibody to synthesize the ADC molecule IMGC936 (Izeltabart Tapatansine) . Izeltabart can be used in the study of cancer[1].
Product Specifications
CAS Number
[2642078-60-0]
Product Name Alternative
IMGC-936 antibody; MGA021
UNSPSC
12352203
Target
ADC Antibody; MMP
Type
Inhibitory Antibodies
Related Pathways
Antibody-drug Conjugate/ADC Related; Metabolic Enzyme/Protease
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/izeltabart.html
Purity
99.91
Solubility
10 mM in DMSO
Smiles
[Izeltabart]
Molecular Weight
(147.4 kDa)
References & Citations
[1]Juniper A Scribner, et al. Preclinical Evaluation of IMGC936, a Next-Generation Maytansinoid-based Antibody-drug Conjugate Targeting ADAM9-expressing Tumors. Mol Cancer Ther. 2022 Jul 5;21 (7) :1047-1059.
Shipping Conditions
Dry Ice
Storage Conditions
Store at -80°C for 2 years
Scientific Category
Inhibitory Antibodies
Clinical Information
Phase 2
Available Sizes
Curated Selection
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