SKP1 Recombinant Antibody, Biotin Conjugated
Product Specifications
Background
Essential component of the SCF (SKP1-CUL1-F-box protein) ubiquitin ligase complex, which mediates the ubiquitination of proteins involved in cell cycle progression, signal transduction and transcription. In the SCF complex, serves as an adapter that links the F-box protein to CUL1. The functional specificity of the SCF complex depends on the F-box protein as substrate recognition component. SCF (BTRC) and SCF (FBXW11) direct ubiquitination of CTNNB1 and participate in Wnt signaling. SCF (FBXW11) directs ubiquitination of phosphorylated NFKBIA. SCF (BTRC) directs ubiquitination of NFKBIB, NFKBIE, ATF4, SMAD3, SMAD4, CDC25A, FBXO5, CEP68 and probably NFKB2.
Synonyms
OCP2; p19A; EMC19; SKP1A; OCP-II; TCEB1L.
Gene ID
6500
Swiss Prot
P63208
Cellular Locus
Extracellular, Cytoplasm, Nucleus, Secreted
Host
Rabbit
Cross Reactivity
Human, Mouse, Rat
Target
SKP1
Clonality
Recombinant
Conjugation
Biotin
Source
KLH conjugated synthetic peptide derived from human SKP1
Applications
WB
Purification
Purified by Protein A.
Concentration
Lot dependent
Dilution
WB (1:300-5000)
Buffer
Aqueous buffered solution containing 0.01M TBS (pH 7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
Modification
Unmodified
Storage Conditions
Store at -20°C for 12 months.
Gene ID URL
6500
Isotype
IgG
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