FADD Recombinant Antibody, Biotin Conjugated
Product Specifications
Background
Apoptotic adapter molecule that recruits caspases CASP8 or CASP10 to the activated FAS/CD95 or TNFRSF1A/TNFR-1 receptors. The resulting aggregate called the death-inducing signaling complex (DISC) performs CASP8 proteolytic activation. Active CASP8 initiates the subsequent cascade of caspases mediating apoptosis. Involved in interferon-mediated antiviral immune response, playing a role in the positive regulation of interferon signaling.
Synonyms
FADD protein; GIG3; Growth inhibiting gene 3 protein; Mediator of receptor induced toxicity; MORT1.
Gene ID
14082
Swiss Prot
Q61160
Cellular Locus
Cytoplasm
Host
Rabbit
Cross Reactivity
Mouse
Target
FADD
Clonality
Recombinant
Conjugation
Biotin
Source
KLH conjugated synthetic peptide derived from mouse Fadd
Applications
WB, IHC-P, IHC-F
Purification
Purified by Protein A.
Concentration
Lot dependent
Dilution
WB (1:300-5000), IHC-P (1:200-400), IHC-F (1:100-500)
Buffer
Aqueous buffered solution containing 0.01M TBS (pH 7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
Modification
Unmodified
Storage Conditions
Store at -20°C for 12 months.
Gene ID URL
14082
Isotype
IgG
Curated Selection
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