NNK (Standard)
NNK (Standard) is the analytical standard of NNK. This product is intended for research and analytical applications. NNK is a nicotine-nitrosated derivative. NNK simultaneously stimulates Bcl2 phosphorylation exclusively at Ser70 and c-Myc at Thr58 and Ser62 through activation of both ERK1/2 and PKCα[1]. NNK induces survival and proliferation of human lung cancer cells. NNK can be used for lung cancer mice model structure[2].
Product Specifications
CAS Number
64091-91-4
UNSPSC
12352005
Target
Endogenous Metabolite; Reference Standards
Type
Reference Standards
Related Pathways
Metabolic Enzyme/Protease; Others
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/nnk-standard.html
Smiles
O=C(C1=CC=CN=C1)CCCN(C)N=O
Molecular Formula
C10H13N3O2
Molecular Weight
207.23
References & Citations
[1]Jin Z, et al. Tobacco-specific nitrosamine 4- (methylnitrosamino) -1- (3-pyridyl) -1-butanone promotes functional cooperation of Bcl2 and c-Myc through phosphorylation in regulating cell survival and proliferation. J Biol Chem. 2004;279 (38) :40209-40219.|[2]Castonguay A, et al. Lung tumorigenicity of NNK given orally to A/J mice: its application to chemopreventive efficacy studies. Exp Lung Res. 1991;17 (2) :485-499.
Shipping Conditions
Room temperature
Scientific Category
Reference Standards
Available Sizes
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