Phospho-CRK (Tyr221) Recombinant Antibody, PE-Cy5 Conjugated
Product Specifications
Background
The Crk-I and Crk-II forms differ in their biological activities. Crk-II has less transforming activity than Crk-I. Crk-II mediates attachment-induced MAPK8 activation, membrane ruffling and cell motility in a Rac-dependent manner. Involved in phagocytosis of apoptotic cells and cell motility via its interaction with DOCK1 and DOCK4. May regulate the EFNA5-EPHA3 signaling.
Synonyms
Adapter molecule crk; avian sarcoma virus CT10 (v-crk) oncogene homolog; CRK; CRKII; Proto-oncogene c-Crk.
Gene ID
1398
Swiss Prot
P46108
Modification Site
Tyr221
Cellular Locus
Cytoplasm, Cell membrane
Host
Rabbit
Cross Reactivity
Human
Target
CRK (Tyr221)
Clonality
Recombinant
Conjugation
PE-Cy5
Source
KLH conjugated synthetic peptide derived from human CRK around the phosphorylation site of Y221
Applications
WB
Purification
Purified by Protein A.
Excitation Emission
488nm/670nm
Concentration
Lot dependent
Dilution
WB (1:300-5000)
Buffer
Aqueous buffered solution containing 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
Modification
Phosphorylation
Storage Conditions
Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.
Gene ID URL
1398
Isotype
IgG
Curated Selection
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