ULK3 Recombinant Antibody, PE-Cy7 Conjugated
Product Specifications
Background
Serine/threonine protein kinase that acts as a regulator of Sonic hedgehog (SHH) signaling and autophagy. Acts as a negative regulator of SHH signaling in the absence of SHH ligand: interacts with SUFU, thereby inactivating the protein kinase activity and preventing phosphorylation of GLI proteins (GLI1, GLI2 and/or GLI3) . Positively regulates SHH signaling in the presence of SHH: dissociates from SUFU, autophosphorylates and mediates phosphorylation of GLI2, activating it and promoting its nuclear translocation.
Synonyms
Serine/threonine-protein kinase ULK3; Ulk3; unc 51 like kinase 3 (C. elegans) ; Unc-51-like kinase 3.
Gene ID
25989
Swiss Prot
Q6PHR2
Cellular Locus
Nucleus
Host
Rabbit
Cross Reactivity
Human
Target
ULK3
Clonality
Recombinant
Conjugation
PE-Cy7
Source
KLH conjugated synthetic peptide derived from human ULK3
Applications
WB, Flow-Cyt
Purification
Purified by Protein A.
Excitation Emission
488nm/780nm
Concentration
Lot dependent
Dilution
WB (1:300-5000), Flow-Cyt (1ug/Test)
Buffer
Aqueous buffered solution containing 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
Modification
Unmodified
Storage Conditions
Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.
Gene ID URL
25989
Isotype
IgG
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