ULK3 Recombinant Antibody, APC Conjugated
Product Specifications
Background
Serine/threonine protein kinase that acts as a regulator of Sonic hedgehog (SHH) signaling and autophagy. Acts as a negative regulator of SHH signaling in the absence of SHH ligand: interacts with SUFU, thereby inactivating the protein kinase activity and preventing phosphorylation of GLI proteins (GLI1, GLI2 and/or GLI3) . Positively regulates SHH signaling in the presence of SHH: dissociates from SUFU, autophosphorylates and mediates phosphorylation of GLI2, activating it and promoting its nuclear translocation.
Synonyms
Serine/threonine-protein kinase ULK3; Ulk3; unc 51 like kinase 3 (C. elegans) ; Unc-51-like kinase 3.
Gene ID
25989
Swiss Prot
Q6PHR2
Cellular Locus
Nucleus
Host
Rabbit
Cross Reactivity
Human
Target
ULK3
Clonality
Recombinant
Conjugation
APC
Source
KLH conjugated synthetic peptide derived from human ULK3
Applications
WB, IF, Flow-Cyt
Purification
Purified by Protein A.
Excitation Emission
650nm/660nm
Concentration
Lot dependent
Dilution
WB (1:300-5000), IF (), Flow-Cyt (1ug/Test)
Buffer
Aqueous buffered solution containing 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
Modification
Unmodified
Storage Conditions
Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.
Gene ID URL
25989
Isotype
IgG
Curated Selection
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