7,3',4'-Trihydroxyisoflavone
7,3',4'-Trihydroxyisoflavone, a major metabolite of Daidzein, is an ATP-competitive inhibitor of Cot (Tpl2/MAP3K8) and MKK4. 7,3',4'-Trihydroxyisoflavone has anticancer, anti-angiogenic, chemoprotective, and free radical scavenging activities[1][2].
Product Specifications
CAS Number
485-63-2
UNSPSC
12352005
Hazard Statement
H302, H312, H332
Target
Apoptosis; MAP3K
Type
Reference compound
Related Pathways
Apoptosis; MAPK/ERK Pathway
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/7-3-4-trihydroxyisoflavone.html
Purity
99.83
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
OC1=CC=C2C(C(C3=CC(O)=C(C=C3)O)=COC2=C1)=O
Molecular Formula
C15H10O5
Molecular Weight
270.24
Precautions
H302, H312, H332
References & Citations
[1]Yu-Li Lo, et al. 7,3',4'-Trihydroxyisoflavone modulates multidrug resistance transporters and induces apoptosis via production of reactive oxygen species. Toxicology. 2012 Dec 16;302 (2-3) :221-32. |[2]Dong Eun Lee, et al. 7,3',4'-Trihydroxyisoflavone, a metabolite of the soy isoflavone daidzein, suppresses ultraviolet B-induced skin cancer by targeting Cot and MKK4. J Biol Chem. 2011 Apr 22;286 (16) :14246-56.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C, 3 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Frequently Asked Questions
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