(R) -YNT-3708
(R) -YNT-3708 is a selective orexin 1 (OX1R) agonist, with an EC50 of 7.48 nM. (R) -YNT-3708 has antinociceptive effects[1].
Product Specifications
CAS Number
[2923137-94-2]
UNSPSC
12352005
Target
Orexin Receptor (OX Receptor)
Type
Reference compound
Related Pathways
GPCR/G Protein; Neuronal Signaling
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/r-ynt-3708.html
Purity
99.07
Solubility
DMSO : 100 mg/mL (ultrasonic; warming; heat to 60°C)
Smiles
O=C(N(C)[C@@H]1CCCC2=C1C=C(NS(=O)(C3=CC(/C=C/C(NC4=CC=NC=C4)=O)=CC=C3OC)=O)C=C2)CC5=CC=CC(OC)=C5
Molecular Formula
C35H36N4O6S
Molecular Weight
640.75
References & Citations
[1]Iio K, et al. Design and Synthesis of Orexin 1 Receptor-Selective Agonists. J Med Chem. 2023 Apr 27;66 (8) :5453-5464.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
OX1 Receptor; OX2 Receptor
Available Sizes
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