Cyclin H Recombinant Antibody, Cy7 Conjugated
Product Specifications
Background
Regulates CDK7, the catalytic subunit of the CDK-activating kinase (CAK) enzymatic complex. CAK activates the cyclin-associated kinases CDK1, CDK2, CDK4 and CDK6 by threonine phosphorylation. CAK complexed to the core-TFIIH basal transcription factor activates RNA polymerase II by serine phosphorylation of the repetitive C-terminal domain (CTD) of its large subunit (POLR2A), allowing its escape from the promoter and elongation of the transcripts. Involved in cell cycle control and in RNA transcription by RNA polymerase II. Its expression and activity are constant throughout the cell cycle.
Synonyms
CAK; CCNH; CDK-activating kinase; cyclin H; cyclin-dependent kinase-activating kinase; Cyclin-H; MO15-associated protein; p34; p37.
Gene ID
902
Swiss Prot
P51946
Cellular Locus
Nucleus
Host
Rabbit
Cross Reactivity
Human, Mouse
Target
Cyclin H
Clonality
Recombinant
Conjugation
Cy7
Source
KLH conjugated synthetic peptide derived from human Cyclin H
Applications
WB, IF, Flow-Cyt
Purification
Purified by Protein A.
Excitation Emission
743nm/767nm
Concentration
Lot dependent
Dilution
WB (1:300-5000), IF (), Flow-Cyt (1ug/Test)
Buffer
Aqueous buffered solution containing 0.01M TBS (pH 7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
Modification
Unmodified
Storage Conditions
Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.
Product Datasheet
https://www.biossantibodies.com/datasheets/bsm-61446R-Cy7
Gene ID URL
902
Isotype
IgG
Curated Selection
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