Human CHMP2B Protein

<strong>Human CHMP2B Protein</strong>_x000D_ <strong>Catalog number:</strong> B2011942_x000D_ <strong>Lot number:</strong> Batch Dependent_x000D_ <strong>Expiration Date:</strong> Batch dependent_x000D_ <strong>Amount:</strong> 100 µg_x000D_ <strong>Molecular Weight or Concentration:</strong> 0.5 mg/mL_x000D_ <strong>Supplied as:</strong> Solution_x000D_ <strong>Applications:</strong> molecular tool for various biochemical applications_x000D_ <strong>Storage:</strong> -20 °C_x000D_ <strong>Keywords:</strong> CHMPB 2, VPS2-2 protein, DMT1 protein, DKFZp564O123 protein, CHMP2.5 protein, VPS2B protein, CHMPB-2, CHMPB 2 protein, CHMPB-2 protein, CHMP2B_x000D_ <strong>Grade:</strong> Biotechnology grade. All products are highly pure. All solutions are made with Type I ultrapure water (resistivity &gt;18 MΩ-cm) and are filtered through 0.22 um._x000D_ _x000D_ <strong>References:</strong>_x000D_ 1: Olszewska DA, Lonergan R, Fallon EM, Lynch T. Genetics of Frontotemporal Dementia Curr Neurol Neurosci Rep. 2016 Dec;16(12):107._x000D_ 2: Midani-Kurçak JS, Dinekov M, Puladi B, Arzberger T, Köhler C. Effect of tau-pathology on charged multivesicular body protein 2b (CHMP2B) Brain Res. 2019 Mar 1;1706:224-236._x000D_ 3: Wilson C, Kavaler J, Ahmad ST. Expression of a human variant of CHMP2B linked to neurodegeneration in Drosophila external sensory organs leads to cell fate transformations associated with increased Notch activity Dev Neurobiol. 2020 Mar;80(3-4):85-97._x000D_ 4: Deng X, Sun X, Yue W, Duan Y, Hu R, Zhang K, Ni J, Cui J, Wang Q, Chen Y, Li A, Fang Y. CHMP2B regulates TDP-43 phosphorylation and cytotoxicity independent of autophagy via CK1 J Cell Biol. 2022 Jan 3;221(1):e202103033._x000D_ 5: Chua JP, De Calbiac H, Kabashi E, Barmada SJ. Autophagy and ALS: mechanistic insights and therapeutic implications Autophagy. 2022 Feb;18(2):254-282._x000D_ 6: Feng Q, Luo Y, Zhang XN, Yang XF, Hong XY, Sun DS, Li XC, Hu Y, Li XG, Zhang JF, Li X, Yang Y, Wang Q, Liu GP, Wang JZ. MAPT/Tau accumulation represses autophagy flux by disrupting IST1-regulated ESCRT-III complex formation: a vicious cycle in Alzheimer neurodegeneration Autophagy. 2020 Apr;16(4):641-658._x000D_ 7: Shi Y, Lin S, Staats KA, Li Y, Chang WH, Hung ST, Hendricks E, Linares GR, Wang Y, Son EY, Wen X, Kisler K, Wilkinson B, Menendez L, Sugawara T, Woolwine P, Huang M, Cowan MJ, Ge B, Koutsodendris N, Sandor KP, Komberg J, Vangoor VR, Senthilkumar K, Hennes V, Seah C, Nelson AR, Cheng TY, Lee SJ, August PR, Chen JA, Wisniewski N, Hanson-Smith V, Belgard TG, Zhang A, Coba M, Grunseich C, Ward ME, van den Berg LH, Pasterkamp RJ, Trotti D, Zlokovic BV, Ichida JK. Haploinsufficiency leads to neurodegeneration in C9ORF72 ALS/FTD human induced motor neurons Nat Med. 2018 Mar;24(3):313-325._x000D_ 8: Krasniak CS, Ahmad ST. The role of CHMP2B(Intron5) in autophagy and frontotemporal dementia Brain Res. 2016 Oct 15;1649(Pt B):151-157._x000D_ 9: De Franceschi N, Alqabandi M, Miguet N, Caillat C, Mangenot S, Weissenhorn W, Bassereau P. The ESCRT protein CHMP2B acts as a diffusion barrier on reconstituted membrane necks J Cell Sci. 2018 Aug 3;132(4):jcs217968._x000D_ <a href="https://pubmed.ncbi.nlm.nih.gov/34281622">10: Coyne AN, Rothstein JD. The ESCRT-III protein VPS4, but not CHMP4B or CHMP2B, is pathologically increased in familial and sporadic ALS neuronal nuclei Acta Neuropathol Commun. 2021 Jul 19;9(1):127. </a>_x000D_ _x000D_ <strong>Products Related to Human CHMP2B Protein can be found at</strong> <a href="https://moleculardepot.com/product-category/Proteins/"> Proteins</a>